Mayo Regional opened in 1978 and is governed by Hospital Administrative District 4, which was established by 12 towns to serve the healthcare needs of residents in a three-county area of rural central Maine.

Mayo Hospital has 22 physicians and 355 staff members dedicated to providing acute medical/surgical care, intensive care, surgical services and obstetrics in an inpatient setting, as well as a wide array of outpatient services.

Mayo Practice Associates, a department of the hospital, owns and operates eight physician practices in Corinna, Dexter, Dover-Foxcroft, Guilford and Milo.